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Effect of di-isopropyl fluorphosphate (DFP) on action potential and cholinesterase of nerve, II. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC(50) values in the low micromolar range and induce hyperacetylation of histones in whole cells. Anisotropic stress orients remodelling of mammalian limb bud ectoderm. These studies indicated that the pool of cholesterol at the active site of the enzyme can determine the rate of pregnenolone biosynthesis in the mitochondria of rat corpus luteum. Early detection by taking an accurate drug history allows the dentist and hygienist to develop a personalized preventive treatment plan, including frequent recalls.
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